SOSIALISASI PLATELET RICH PLASMA (PRP) ALOGENIK SEBAGAI TERAPI PENDUKUNG DIABETES MELLITUS PADA TENAGA KESEHATAN DI FASILITAS KESEHATAN KOTA SEMARANG
Abstract
Diabetes mellitus is a non-communicable disease with an increasing prevalence and is often accompanied by chronic complications, one of which is diabetic foot ulcers that are difficult to heal and have a high risk of infection and amputation. Conventional management of diabetic wounds often fails to produce optimal results, necessitating innovative and evidence-based supportive therapies. Platelet-Rich Plasma (PRP) is a blood-derived product rich in growth factors that has the potential to accelerate wound healing. Although the potential of PRP has been widely reported, healthcare professionals' understanding and readiness to apply it remain limited, particularly in primary healthcare facilities. This community service activity aims to increase the knowledge and understanding of health workers regarding allogeneic PRP, including topical or spray formulations, as a supportive therapy in the treatment of diabetic wounds. The community service method was carried out through educational and knowledge dissemination activities, which included material presentations, interactive discussions, and demonstrations of the use of PRP on diabetic wounds using simulation media. The activity was carried out at the Indonesian Red Cross in Semarang City, involving health workers from the Indonesian Red Cross and affiliated health care facilities. The material presented covered the basic concepts of PRP, the mechanism of PRP in wound healing, the differences between autologous and allogeneic PRP, and the principles of using topical or spray PRP. Data were obtained through observation during the activity and participant responses, then analyzed using descriptive qualitative methods. The novelty of this activity was the introduction of allogeneic PRP in topical or spray form as a supportive therapy for diabetic wounds to health workers, which is still relatively rarely applied in health service practice. The results of the activity showed an increase in participants' understanding, enthusiasm, and readiness to consider the use of PRP as part of rational and safe diabetes wound management. It was concluded that this community service activity could increase healthcare workers' knowledge of the use of allogeneic PRP as a supportive therapy for diabetic wounds and has the potential to encourage the adoption of evidence-based regenerative therapies in healthcare facilities.
References
W. Fan, “Epidemiology in diabetes mellitus and cardiovascular disease,” Cardiovasc. Endocrinol., vol. 6, no. 1, pp. 8–16, Mar. 2017, doi: 10.1097/XCE.0000000000000116.
S. Raghavan et al., “Diabetes Mellitus–Related All‐Cause and Cardiovascular Mortality in a National Cohort of Adults,” J. Am. Heart Assoc., vol. 8, no. 4, Feb. 2019, doi: 10.1161/JAHA.118.011295.
A. H. Heald et al., “Estimating life years lost to diabetes: outcomes from analysis of National Diabetes Audit and Office of National Statistics data,” Cardiovasc. Endocrinol. Metab., vol. 9, no. 4, pp. 183–185, Dec. 2020, doi: 10.1097/XCE.0000000000000210.
J. C. N. Chan et al., “The Lancet Commission on diabetes: using data to transform diabetes care and patient lives,” The Lancet, vol. 396, no. 10267, pp. 2019–2082, Dec. 2020, doi: 10.1016/S0140-6736(20)32374-6.
D. J. Magliano et al., “Trends in incidence of total or type 2 diabetes: systematic review,” BMJ, p. l5003, Sep. 2019, doi: 10.1136/bmj.l5003.
V. Hani Agustin et al., “Pengaruh Senam Diabetes terhadap Kadar Glukosa Darah pada Pasien Diabetes Mellitus di Puskesmas Gunungpati,” Jurnal Riset Rumpun Ilmu Kesehatan, vol. 4, pp. 167–175, 2025, doi: 10.55606/jurrikes.v4i3.6509.
E. Enjelia, M. Frisilia, and R. Ovany, “Hubungan Tingkat Pengetahuan dengan Perilaku Pola Makan Sebagai Faktor Risiko Terjadinya Diabetes Melitus (DM) pada Siswa Kelas X di SMA Negeri 4 Palangka Raya,” Jurnal Surya Medika, vol. 10, no. 2, pp. 254–263, Aug. 2024, doi: 10.33084/jsm.v10i2.7751.
M. Fathan et al., “Memahami Definisi, Penyebab Dan Gejala Diabetes Melitus Melalui Kegiatan Penyuluhan Masyarakat Di Posyandu Kemuning Ii Kelurahan Klender,” 2025.
M. S. Baig et al., “An Overview of Diabetic Foot Ulcers and Associated Problems with Special Emphasis on Treatments with Antimicrobials,” ., vol. 12, no. 7, p. 1054, Jul. 2022, doi: 10.3390/life12071054.
P. Caruso et al., “Long-term diabetic complications as predictors of foot ulcers healing failure: A retrospective study in a tertiary-care center,” Diabetes Res. Clin. Pract., vol. 163, p. 108147, May 2020, doi: 10.1016/j.diabres.2020.108147.
A. Iqbal, A. Jan, M. A. Wajid, and S. Tariq, “Management of Chronic Non-healing Wounds by Hirudotherapy.,” World J. Plast. Surg., vol. 6, no. 1, pp. 9–17, Jan. 2017.
Z. Moore et al., “Diabetic foot ulcers: treatment overview and cost considerations,” J. Wound Care, vol. 30, no. 10, pp. 786–791, Oct. 2021, doi: 10.12968/jowc.2021.30.10.786.
A. Jodheea-Jutton, S. Hindocha, and A. Bhaw-Luximon, “Health economics of diabetic foot ulcer and recent trends to accelerate treatment,” The Foot, vol. 52, p. 101909, Sep. 2022, doi: 10.1016/j.foot.2022.101909.
G. Mulder, M. Tenenhaus, and G. F. D’Souza, “Reduction of Diabetic Foot Ulcer Healing Times Through Use of Advanced Treatment Modalities,” Int. J. Low. Extrem. Wounds, vol. 13, no. 4, pp. 335–346, Dec. 2014, doi: 10.1177/1534734614557925.
E. Zanzov, V. Anastasova, K. Ivanova, and P. Kiskinov, “Platelet-Rich Plasma for Wound Healing in Diabetic Patients,” Medicina (B Aires)., vol. 61, no. 9, p. 1535, Aug. 2025, doi: 10.3390/medicina61091535.
H. Xu, K. Huang, and X. Tao, “Efficacy and safety of platelet-rich plasma versus conventional care in diabetic foot ulcers: a meta-analysis of randomized controlled trials,” Acta Diabetol., vol. 62, no. 10, pp. 1585–1596, Jul. 2025, doi: 10.1007/s00592-025-02555-7.
D. O. T. J. W. R. M. Intania Riska Putrie, “Efektivitas Penggunaan Platelet Rich Plasma (Prp) Pada Penderita Diabetic Foot Ulcer,” Medika Tadulako: Jurnal Ilmiah Kedokteran Fakultas Kedokteran, 2023.
E. Emeliawati, S. Sriyati, and W. Widiastuti, “Pengaruh Edukasi Perawatan Kaki terhadap Pencegahan Diabetic Foot Ulcer pada Pasien Diabetes,” Jurnal Keperawatan Suaka Insan (JKSI), vol. 10, no. 1, pp. 24–33, Jan. 2025, doi: 10.51143/jksi.v10i1.741.
